AN UNBIASED VIEW OF LDN-27219 DRUG MECHANISM OF ACTION

Just one notably intriguing compound is LDN-27219. Although most tTG inhibitors are made to bind to the protein crosslinking Lively web site, LDN-27219 as an alternative binds towards the nucleotide binding pocket from the enzyme while it is in its shut-state conformation, and stabilizes that conformation to prevent crosslinking activity.seventy ei